Carol Hall

Bio

Carol K. Hall is the Worley H Clark, Jr, Distinguished University Professor of Chemical and Biomolecular Engineering at NC State. Hall’s research is driven by her fascination with molecules of interesting architectures and energetics, and by her desire to understand how these molecular features combine to yield complex mesoscopic or macroscopic features. Her primary tool in this effort is computer simulation, which permits the visualization of systems on a molecular level. These techniques are used to model the self-assembly of proteins whose aggregation is implicated in Alzheimer’s and other neurodegenerative diseases. A new research area is the design of short peptides to bind to specific biomolecular targets including RNA and proteins. Peptides have been designed to bind to Cardiac Troponin I (a heart attack biomarker), the Fab and FC domains on monoclonal antibodies, C difficile bacteria’s Toxins A and B, the SARS-CoV receptor, and microplastics. Hall’s research is informed and enriched by interactions with experimental colleagues at NC State, and across the world.