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Global One Health Academy

Fernando Luis Barroso da Silva

FL

Associate Professor, University of São Paulo

he/him/his

Bio

Associate Professor Fernando Barroso graduated in Physics from the State University of São Paulo, Brazil, in 1994. After a Ph.D. thesis under Bo Jönsson on the statistical mechanical studies of aqueous solutions and biomolecular systems, he obtained his Ph.D. degree in Theoretical Chemistry at the University of Lund, Sweden, and joined as a Research Assistant in the Department of Physics at the State University of São Paulo. In 2001, he moved to the Department of Physics and Chemistry of the School of Pharmaceutical Sciences at Ribeirão Preto, University of São Paulo, Brazil, as an Assistant Professor. He was subsequently appointed an Associate Professor in Molecular Biophysics at the Department of Biomolecular Sciences where he researched fundamental forces in Molecular Biophysics (particularly protein electrostatics), Molecular Modeling, and Computational Virology. Biomolecular interactions and data-driven science are the central research topics in all his interdisciplinary projects. The Barroso Research lab is where Structural Bioinformatics, Molecular Biophysics, Physical Chemistry, Medicine, Food, and Pharma meet. As the head of the lab, he applies his innovative computational technology to offer a rational approach to the understanding of infectious diseases at the molecular level and the discovery of therapeutic agents, biomarkers, and their controlled release. Actively engaged in fostering scientific partnerships worldwide, he frequently serves as a visiting researcher/professor at universities in Sweden, the USA, France, Poland, and Ireland, contributing to initiatives that promote a better quality of life and education​.

Recent Publications

  • Valotto, R.S.; Barroso da Silva, F.L.; Lyra Júnior, P.C.M.; Machado de Ávila, R.A.; Campos, F.V.; Costa, D.S.; Guimarães, M.C.C.; Consensus-Based In Silico Mapping of NS1 Antigenic Determinants in Dengue and Zika Viruses to Improve Diagnostic Specificity, BMC Infectious Diseases, submitted.
  • Ashraf, FB; Zhang, Z.; Paco, K.; Ojeda, C.J.D.; Mendivil, M.P.; Lay, J.A.; Yang, T.Y.; Barroso da Silva, F.L.; Sazinsky, M.H.; Ray, A.; Lonardi, S.; A Large Language Model Guides the Affinity Maturation of Variant Antibodies Generated by Combinatorial Optimization Algorithms, bioRxiv, preprint (submitted to Nucleic Acids Research). (DOI:10.1101/2024.12.19.629473)
  • Grandguillaume, I.; Barroso da Silva, F.L.; Etchebest, C.; ANABAG: Annotated Antibody Antigen dataset with unique features for Antibody Engineering Applications, bioRxiv, preprint (submitted to J. Chemical Information and Modeling). (DOI:10.1101/2025.07.03.663065)
  • Carvaillo, J.; Tubiana, T.; Detchanamourtty, S.; Bressanelli, S.; Barroso da Silva, F.L.; Boulard, Y.; Studying self-assembly of norovirus capsid by a combination of in silico methods, bioRxiv, preprint (submitted to J. Biomol. Struct. Dyn.). (DOI: 10.1101/2024.01.21.575142)
  • Barroso da Silva, F.L.; Paco, K.; Laaksonen, A.; Ray, A. Biophysics of SARS‐CoV‐2 spike protein’s receptor‐binding domain interaction with ACE2 and neutralizing antibodies: from computation to functional insights, Biophysical Reviews,17, pp.309-333, 2025. (DOI:10.1007/s12551-025-01276-
  • Barroso da Silva, F.L.; Etchebest, C.; Santiso, E. E.; Giron, C. C.; Grandguillaume, I.; Marques, R. B.; Poveda-Cuevas, S. A., The Barroso Research lab: biomolecular interactions, computing, and data-driven science to understand and engineer biological and pharmaceutical systems in a global academic partnership, Journal of Information and Data Management, 15(1), 242–254, 2024 (DOI:10.5753/jidm.2024.2621).

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