{"id":5374,"date":"2025-01-15T13:14:04","date_gmt":"2025-01-15T18:14:04","guid":{"rendered":"https:\/\/provost.ncsu.edu\/global-one-health-academy\/?page_id=5374"},"modified":"2025-01-15T13:24:31","modified_gmt":"2025-01-15T18:24:31","slug":"antimicrobial-resistance","status":"publish","type":"page","link":"https:\/\/provost.ncsu.edu\/global-one-health-academy\/antimicrobial-resistance\/","title":{"rendered":"Antimicrobial Resistance"},"content":{"rendered":"\n\n\n\n\n

By 2050, it is projected that antimicrobial resistant pathogens will result in the death of 10 million people worldwide \u2013 even more than cancer (8.2 million). The problem is greatly exacerbated by the lack of new antimicrobials to treat these infections, gaps in data exchange, changing climate, the need for rapid diagnostics, and researchers working in silos. NC State has the expertise to overcome these challenges and improve outcomes by targeting AMR at the local, national, and global levels using the One Health lens.<\/p>\n\n\n\n

The Grand Challenges Addressing Program on Antimicrobial Resistance (GCAP-AMR) will catalyze NC State\u2019s tremendous strengths in areas ranging from molecules to population-based approaches, centered around themes including:<\/p>\n\n\n\n

Drug discovery and validation<\/li>\n\n\n\n
Integrated data analytics and reporting<\/li>\n\n\n\n
Machine learning and diagnostics<\/li>\n\n\n\n
Surveillance and reporting<\/li>\n\n\n\n
Climate change and transmission nexus<\/li>\n<\/ul>\n\n\n\n
NC State AMR Research Network<\/strong><\/h3>\n\n\n\n
The network figure below illustrates the diverse faculty at NC State with published research related to AMR. As of fall 2024, faculty members from seven colleges belong to this research network: College of Agriculture & Life Sciences (CALS), College of Veterinary Medicine (CVM), College of Sciences (COS), College of Engineering (COE), Wilson College of Textiles (WCOT), College of Natural Resources (CNR), and College of Humanities & Social Sciences (CHASS). Each node (dot) represents an individual faculty member and each edge (line between the dots) represents a co-authored AMR publication, with the edge width proportional to the number of publications.<\/p>\n\n\n\n
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Nearly 300 faculty belong to this NC State AMR research network, but many of these faculty are working in disciplinary (within-college) silos, and many more are not yet collaborating with other NC State faculty on this research at all. GCAP-AMR aims to change that by incentivizing new interdisciplinary research directions through seed grants and providing opportunities to bring faculty on the outskirts of this figure more firmly into the collaborative network. Harnessing NC State\u2019s full range of AMR expertise will drive innovative One Health solutions.<\/p>\n\n\n\n
GCAP AMR Seed Grants<\/h3>\n\n\n\n
The Global One Health Academy offered seed grants in Fall 2024 to accelerate interdisciplinary AMR research grounded in the One Health framework. Two funding types were available: Launch Projects of up to $50,000 to support more advanced-stage projects likely to lead to external grant submission within a short time window, and Pilot Projects of up to $15,000 to support more nascent collaborations and\/or new research directions. Five projects were funded through this seed grant call.<\/p>\n\n\n\n
Launch Projects<\/h4>\n\n\n\n
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Decoding antimicrobial resistant organisms\u2019 colonization through One Health interdisciplinary research<\/strong>\n
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PIs: Cristina Lanzas (CVM)<\/a>, Casey Theriot (CVM), Josh Fletcher (CVM)<\/a>, Ben Callahan (CVM), Alun Lloyd (COS), Frank Scholle (COS)<\/a>, Reza Ghiladi (COS)<\/a>, Nathan Crook (COE)<\/a>, and Angela Harris (COE)<\/a><\/li>\n<\/ul>\n<\/li>\n\n\n\n
Development of novel antimicrobial materials for infection prevention<\/strong>\n\n
PIs: Reza Ghiladi (COS)<\/a> and Richard Spontak (COE)<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n
Pilot Projects<\/h4>\n\n\n\n
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Sunny-day flooding and AMR organisms: filling a ONE health knowledge gap to understand human health risks posed by rising sea levels<\/strong>\n\n
PIs: Angela Harris (COE)<\/a>, Natalie Nelson (CALS)<\/a>, Katherine Anarde (COE), and Benjamin Callahan (CVM)<\/li>\n<\/ul>\n<\/li>\n\n\n\n
GOHA STARS: Student-driven Tiny earth Antimicrobial Resistance Solutions<\/strong>\n\n
PIs: Stephanie Mathews (COS)<\/a>, Nathalie Lavoine (CNR)<\/a>, and Michael Taveirne (COS)<\/li>\n<\/ul>\n<\/li>\n\n\n\n
Machine Learned Synergistic Antibiotic Combinations to Expand Access to Therapies<\/strong>\n\n
PIs: Kaixiong Zhou (COE)<\/a>, Albert Keung (COE)<\/a>, and Yi-Hui Zhou (COS)<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n
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Learn more about these projects<\/span>\n
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news in gcap-amr<\/h2>\n <\/div>\n
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GCAP Antimicrobial Resistance Seed Grants Awarded<\/h3>\n \n\n \t \t
Over the summer GOHA launched the Grand Challenges Addressing Program (GCAP) \u2013 to address wicked problems that demand an interdisciplinary approach. To accelerate this effort, GOHA awarded seed grants for interdisciplinary AMR research.
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Accepting Proposals for GCAP-AMR Seed Grants<\/h3>\n \n\n \t \t
The Global One Health Academy is excited to announce a call for proposals for their new GCAP-AMR Seed grants. These grants will fund NC State faculty pursuing interdisciplinary AMR research. Background…
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GCAP Catalysis Meeting on Antimicrobial Resistance – July 23, 2024<\/h3>\n \n\n \t \t
The Global One Health Academy is proud to announce a new initiative, Grand Challenge Addressing Program (GCAP), to address wicked problems that demand an interdisciplinary approach. To kick off this…
By 2050, it is projected that antimicrobial resistant pathogens will result in the death of 10 million people worldwide \u2013 even more than cancer (8.2 million). The problem is greatly…<\/p>\n","protected":false},"author":255,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"source":"","ncst_dynamicHeaderBlockName":"ncst\/split-header","ncst_dynamicHeaderData":"{\"backgroundColor\":\"red_400\",\"imageID\":5379,\"imageURL\":\"https:\/\/provost.ncsu.edu\/global-one-health-academy\/wp-content\/uploads\/sites\/3\/2025\/01\/MH10975-scaled-e1736965458156.jpg\",\"pageIntro\":\"GCAP-AMR supports interdisciplinary research to combat the silent pandemic of antimicrobial resistance at the human-animal-plant-environment interface.<\/em>\",\"mirrorLayout\":true,\"imageAlt\":\"\",\"focalPoint\":{\"x\":0.41,\"y\":0.24}}","ncst_content_audit_freq":"","ncst_content_audit_date":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-5374","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/provost.ncsu.edu\/global-one-health-academy\/wp-json\/wp\/v2\/pages\/5374","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/provost.ncsu.edu\/global-one-health-academy\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/provost.ncsu.edu\/global-one-health-academy\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/provost.ncsu.edu\/global-one-health-academy\/wp-json\/wp\/v2\/users\/255"}],"replies":[{"embeddable":true,"href":"https:\/\/provost.ncsu.edu\/global-one-health-academy\/wp-json\/wp\/v2\/comments?post=5374"}],"version-history":[{"count":10,"href":"https:\/\/provost.ncsu.edu\/global-one-health-academy\/wp-json\/wp\/v2\/pages\/5374\/revisions"}],"predecessor-version":[{"id":5400,"href":"https:\/\/provost.ncsu.edu\/global-one-health-academy\/wp-json\/wp\/v2\/pages\/5374\/revisions\/5400"}],"wp:attachment":[{"href":"https:\/\/provost.ncsu.edu\/global-one-health-academy\/wp-json\/wp\/v2\/media?parent=5374"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}